Pharmacology: Discontinuation of bisphosphonates
نویسندگان
چکیده
منابع مشابه
Bisphosphonates: Mode of Action and Pharmacology
The profound effects of the bisphosphonates on calcium metabolism were discovered over 30 years ago, and they are now well established as the major drugs used for the treatment of bone diseases associated with excessive resorption. Their principal uses are for Paget disease of bone, myeloma, bone metastases, and osteoporosis in adults, but there has been increasing and successful application in...
متن کاملBisphosphonates: mode of action and pharmacology.
The profound effects of the bisphosphonates on calcium metabolism were discovered over 30 years ago, and they are now well established as the major drugs used for the treatment of bone diseases associated with excessive resorption. Their principal uses are for Paget disease of bone, myeloma, bone metastases, and osteoporosis in adults, but there has been increasing and successful application in...
متن کاملDrug discontinuation effects are part of the pharmacology of a drug.
Most reviews of drug withdrawal effects focus on drugs of potential abuse such as opioids, benzodiazepines, etc. Abrupt discontinuation of many other drugs used in medicine cause withdrawal syndromes, some of which can be fatal. Discontinuation of a number of cardiovascular drugs can increase risk of cardiovascular events above that of people not taking these drugs. These include β-adrenergic r...
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Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...
متن کاملAntitumor activity of bisphosphonates.
Introduction Bone metastases are a major cause of morbidity for patients with many types of cancer including multiple myeloma, breast cancer, prostate cancer, and other solid tumors. The clinical complications of bone metastases include pain, fracture, spinal cord compression, and hypercalcemia of malignancy. Although there are important differences in the biology of bone metastases from differ...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2017
ISSN: 0007-0610,1476-5373
DOI: 10.1038/sj.bdj.2017.52